CGM - Scientifique organisation

Department Dynamics and Stability of Genomes

Head of the department: Bénédicte MICHEL

  Last update: 15-Apr-2011

The DSG department is composed of eight teams which study different aspects of chromosome transmission.

Four teams study bacterial chromosomes. François-Xavier Barre studies the role of septum proteins in the chromosome segregation of two bacteria, Escherichia coli and Vibrio cholerae, a pathogen with two circular chromosomes. Frédéric Boccard’s team has defined chromosome domains in E. coli and identified domain-specific proteins responsible for spatial chromosome organisation during and after replication. Bénédicte Michel studies replication impairment and the proteins and pathways that participate in the restart of inactivated replication forks. Olivier Espéli characterizes chromatide cohesion in E. coli and in the yeast Schizosaccharomyces pombe.

The four other teams analyze the transmission and organization of eukaryotic genomes.  Kathrin Marheineke analyzes the control of replication during the early development of Xenopus. Mireille Bétermier’s team characterizes programmed genome rearrangements in Paramecium, a model unicellular eukaryote. Linda Sperling studies evolution and genome organisation of Paramecium using bioinformatics. Claude Thermes studies, also in silico, mammalian genome organization and evolution and the imprinting of DNA replication and transcription on the DNA sequence of the human genome.

The teams are classified following the surname of the team leaders. Please, click on the surname of a leader to go to the Web pages of his (her) team.