L'équipe

Lionello Bossi, Directeur de Recherche, CNRS

Nara Figueroa-Bossi, Chargé de Recherche, CNRS

Qi Yang, Doctorant, China Scholarship Council

Notre adresse

CNRS - Centre de Génétique Moléculaire

Avenue de la Terrasse - Bât. 24

91198 GIF-SUR-YVETTE Cedex

FRANCE

Téléphone : 33 (0)1 69 82 38 11

Fax : 33 (0)1 69 82 38 77

Thématiques de recherche

L’activité de recherche de notre équipe se répartit entre trois thématiques, utilisant comme système modèle d'étude la bactérie Salmonella enterica (serovar Typhimurium).

1. Les mécanismes de régulation par des petits ARN non-codants chez les bactéries : pour en savoir plus

2. Le rôle des bactériophages tempérés dans le transfert horizontal de gènes et dans l’évolution des génomes bactériens : pour en savoir plus

3. Le rôle de l'ADN gyrase dans l'activité biologique de l'ADN : pour en savoir plus

film

Publications récentes

Lemire, S., Figueroa-Bossi, N., Bossi, L. (2011) Bacteriophage Crosstalk: Coordination of Prophage Induction by Trans-Acting Antirepressors. PLoS Genet, 7 (6) e1002149.

Balbontín, R., Fiorini, F., Figueroa-Bossi, N., Casadesús, J. and Bossi, L. (2010). Recognition of heptameric seed sequence underlies multi-target regulation by RybB small RNA in Salmonella enterica. Molecular Microbiology, 78 (2) 380-94.

Effantin, G., Figueroa-Bossi, N., Schoehn, G., Bossi, L., Conway, JF. (2010) The tripartite capsid gene of Salmonella phage Gifsy-2 yields a capsid assembly pathway engaging features from HK97 and lambda. Virology, 402 (2) 355-65.

Figueroa-Bossi, N., Valentini, M., Malleret, L., Fiorini, F., Bossi, L. (2009) Caught at its own game: regulatory small RNA inactivated by an inducible transcript mimicking its target. Genes Dev, 23 (17) 2004-15. Erratum in: Genes Dev. 2010 Apr 1; 24 (7) 734.

Lemire, S., Figueroa-Bossi, N. and Bossi, L. (2008) A singular case of prophage complementation in the mutational activation of recET orthologs in Salmonella enterica serovar Typhimurium. J Bacteriol, 190 (20) 6857-66.

Bossi, L., Maloriol, D. and Figueroa-Bossi, N. (2008) Porin biogenesis activates the s^E response in Salmonella hfq mutants. Biochimie, 90 (10) 1539-44.

Balbontín, R., Figueroa-Bossi, N., Casadesús, J. and Bossi, L. (2008) Insertion hotspot for horizontally acquired DNA within a bidirectional small RNA locus in Salmonella enterica. J Bacteriol, 190 (11) 4075-8.

Bossi, L. and Figueroa-Bossi, N. (2007) A small RNA downregulates LamB maltoporin in Salmonella. Mol Microbiol, 65 (3) 799–810.

Lemire, S. (2006) Les prophages de Salmonella typhimurium : régulation lysogénique et contribution à la pathogénicité. Thèse, Paris-Sud 11.

Figueroa-Bossi, N., Lemire, S., Maloriol, D., Balbontin, R., Casadesus, J. and Bossi, L. (2006) Loss of Hfq activates the sigmaE-dependent envelope stress response in Salmonella enterica. Mol Microbiol, 62 (3) 838-52.

Figueroa-Bossi, N., Ammendola, S. and Bossi, L. (2006) Differences in gene expression and in enzyme properties account for the uneven contribution of superoxide dismutases SodCI and SodCII to pathogenicity in Salmonella enterica. Microbes Infect, 8 (6) 1569-1578.

Alonso, A., Pucciarelli, M., Figueroa-Bossi, N., and Garcia del Portillo, F. (2005). Increased excision of the Salmonella defective prophage ST64B caused by a deficiency in Dam methylase. J Bacteriol, 187 (23) 7901-11. ,

Blanc-Potard, A., Labesse, G., Figueroa-Bossi, N., and Bossi, L. (2005). Mutation at the "exit gate" of the Salmonella gyrase a subunit suppresses a defect in the gyrase B subunit. J Bacteriol, 187, 6841-6844.

Bossi, L., and Figueroa-Bossi, N. (2005). Prophage arsenal of Salmonella enterica serovar Typhimurium. In Phages: Their Role in Bacterial Pathognenesis and Biotechnology, M. Waldor, D. Friedman, and S. Adhya, eds. (Washington, DC, ASM Press).

Coombes, B., Wickham, M., Brown, N., Lemire, S., Bossi, L., Hsiao, W., Brinkman, F., and Finlay, B. (2005). Genetic and molecular analysis of GogB, a phage-encoded type III-secreted substrate in Salmonella enterica serovar typhimurium with autonomous expression from its associated phage. J Mol Biol, 348, 817-830.

Bacciu, D., Falchi, G., Spazziani, A., Bossi, L., Marogna, G., Leori, G., Rubino, S., and Uzzau, S. (2004). Transposition of the heat-stable toxin astA gene into a gifsy-2-related prophage of Salmonella enterica serovar Abortusovis. J Bacteriol, 186, 4568-4574.

Figueroa-Bossi, N., and Bossi, L. (2004). Resuscitation of a defective prophage in Salmonella cocultures. J Bacteriol, 186, 4038-4041.

Bossi, L., Fuentes, J., Mora, G., and Figueroa-Bossi, N. (2003). Prophage contribution to bacterial population dynamics. J Bacteriol, 185, 6467-6471.

Ho, T., Figueroa-Bossi, N., Wang, M., Uzzau S, Bossi, L., and Slauch, J. (2002). Identification of GtgE, a novel virulence factor encoded on the Gifsy-2 bacteriophage of Salmonella enterica serovar Typhimurium. J Bacteriol, 184, 5234-5239.

Uzzau, S., Bossi, L., and Figueroa-Bossi, N. (2002). Differential accumulation of Salmonella [Cu, Zn] superoxide dismutases SodCI and SodCII in intracellular bacteria: correlation with their relative contribution to pathogenicity. Mol Microbiol, 46, 147-156.

Gari, E., Bossi, L., and Figueroa-Bossi, N. (2001). Growth-dependent DNA breakage and cell death in a gyrase mutant of Salmonella. Genetics, 159, 1405-1414.

Uzzau, S., Figueroa-Bossi, N., Rubino, S., and Bossi, L. (2001). Epitope tagging of chromosomal enes in Salmonella. Proc Natl Acad Sci USA, 98, 15264-15269.

Figueroa-Bossi, N., Uzzau, S., Maloriol, D. and Bossi L. (2001) Variable assortment of prophages provides a transferable repertoire of pathogenic determinants in Salmonella. Mol Microbiol, 39, 260-272.